Model Organisms in G Protein–Coupled Receptor Research

Model Organisms in G Protein-Coupled Receptor Research.

The study of G protein-coupled receptors (GPCRs) has benefited greatly from experimental approaches that interrogate their functions in controlled, artificial environments. Working in vitro, GPCR receptorologists discovered the basic biologic mechanisms by which GPCRs operate, including their eponymous capacity to couple to G proteins; their molecular makeup, including the famed serpentine tran...

Model organisms in GPCR research

Institute of Physiology, Department of Neurophysiology, University of Würzburg, Würzburg, Germany (T.L.), Department of Genetics, Rutgers, The State University of New Jersey, Piscataway, NJ, USA (M.M.B.), Department of Anesthesiology, Division of Basic Research and Washington University Pain Center and Department of Anatomy and Neurobiology and Division of Biological and Biomedical Sciences, Wa...

A direct and functional interaction between the trimeric G protein Go and Rab5 in G proteincoupled receptor signaling

Semantic Research Platform for Model Organisms

Model organisms such as budding yeast provide a common platform to interrogate and understand cellular and physiological processes. Knowledge about model organisms, whether generated during the course of scientific investigations, or extracted from published articles, are integrated and made available by model organism databases (MODs) such as the Saccharomyces Genome Database (SGD). SGD uses I...

G-protein Coupled Receptor Dimerization

A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...